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doi: 10.1007/s00018-019-03011-w, 51

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The BBB, composed of brain capillary endothelial cells with their tight junctions, multiple transporters, receptors and metabolizing enzymes, strictly regulates the passage of the molecules in order to avoid the entrance of harmful xenobiotics to the brain

Unfortunately, a phase II clinical trial of UBX0101 (NCT03513016) was completed in patients with osteoarthritis and the promising results observed (Table 1), in vitro and in vivo, have not been up to the expectations in treated patients, leading only to a decrease of pain, without a significant improvement of the disease 30

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Hormone replacement therapy has been shown to mitigate some of these immunological alterations