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Strikingly, accumulation of iron was also detected without the presence of the chelator, suggesting that ABCC1 transports Fe-GSH complexes with an activity of 1130 pmol/mg/l (Fig

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japonicum GST-tagged) or on Ni-affinity (Qiagen, Milan, Italy) (N-6His-tagged) column chromatography according to manufacturer's instructions

This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]

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Molecular cloning and characterization of a novel 3-phosphoadenosine 5-phosphosulfate transporter, PAPST2