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Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study

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AOD 9604 best clinical result was approximately 2.8kg of additional fat loss over 12 weeks, and the larger confirmatory trial (OPTIONS study, 536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

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Over time, however, there is always a certain amount of inactive cob(II)-cobalamin produced, which must be reactivated through methylation into methylcobalamin with the help of a special enzyme