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Under physiological conditions, astrocytes support synaptic transmission by efficiently clearing glutamate via excitatory amino acid transporters (EAAT)1/2 106 , converting it into glutamine and supplying lactate to neurons through aerobic glycolysis 107

S6C), delayed hair regeneration (Fig

After SNP screening, three amino acid indicators were identified: met-a-308 (phenylalanine), met-a-584 (X-12100 hydroxytryptophan), and met-a-337 (5-hydroxyproline), which showed significant causal relationship with the occurrence of PD

for example, deucravacitinib, PF06826647, and brepocitinib selectively act on TYK2

Biterova and Barycki, 2009)

In the brain, NAC modulates the exchange of glutamate, a critical excitatory neurotransmitter