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The choice between pan-PDK inhibition and isoform-specific inhibitors should be guided by the expression profile of PDK isoforms within tumors

The modern diet, which typically contains up to 15 times more omega-6 PUFAs than omega-3 PUFAs, along with a common deficiency of DHA in the brain, results in the production of large amounts of lipid mediators derived from LA and AA, contributing to chronic inflammation and oxidative stress implicated in cardiovascular, metabolic, inflammatory, and neuropsychiatric disorders (50, 5759)

192 Including B 12 with other B vitamins in homocysteine-lowering therapy may enhance efficacy

GSH-MEE (G1404), hydrogen peroxide solution (H 2 O 2 , 95321), TNF (SRP3177), and DAPI (D9542) were from Sigma-Aldrich (St

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doi: 10.3389/fncel.2022.869546 83 HuX.LiP.GuoY.WangH.LeakR