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LLK, LPK, and pEK all reduced melanin content and tyrosinase activity, with PEK exhibiting the strongest inhibitory effect

R.DawsonG.et al (2010)

64 (44), e202509183

Figure 2 6 Future directions and conclusions Emerging evidence from both clinical and preclinical studies suggests that exercise and vitamin D may exert complementary effects on brain aging, particularly in domains such as cognitive function, neuroprotection, and systemic aging markers

Since most reactions in the second stage are spontaneous, tyrosinase acts as the rate-limiting enzyme in melanin synthesis, making it the primary enzyme involved in both enzymatic browning and melanin production 7