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This increased laxity is attributed to estrogens influence on the collagen structure, leading to a temporary decrease in the ligaments stiffness and strength

Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

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However, the field must confront the limitations of reductionist models by embracing systems-level approaches that account for the biological and environmental complexity of AUD and depression