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The formation of NFT in an aerobic intracellular environment raises the question of its stability and its interaction with biological molecules such as the omnipresent glutathione

One possible scenario is the metabolic cofactor NADPH, which is known to be required not only for lipid synthesis but also for the function of antioxidant reductases, such as glutathione reductase (GSR) and thioredoxin reductase (TXNRD) 86

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Saeedi, P

doi: 10.4049/jimmunol.169.3.1228 27 SzatmariIRajnavolgyiENagyL