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Lewy bodies, once thought to be mere markers, are now considered active participants in disease propagation due to their interaction with endolysosomal and mitochondrial pathways (Dorsey et al., 2024

M.de VosP

Previous studies have discovered that SP couples to PI-PLC through the NK1 receptor in the rat anterior pituitary by binding with GTP, which serves as the substrate for cGAS catalysis of cGAMP formation [29, 30]

ISCs are involved in electron transport, substrate binding, enzymatic catalysis and play critical roles in maintaining genomic stability since several DNA polymerases and helicases require interaction with ISCs for proper functioning