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Most researchers notice initial changes within the first two to four weeks, primarily through reduced appetite and early water weight loss

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These PUFAs are subsequently esterified into phospholipids by lysophosphatidylcholine acyltransferase 3 (LPCAT3), generating PUFA-phospholipids (PUFA-PLs) that are highly susceptible to oxidation by lipoxygenases (ALOXs), ultimately leading to ferroptosis (109, 110)