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Several epidemiological and experimental studies suggest that metformin may exert neuroprotective effects that could be relevant for AD prevention and treatment

On the other hand, glutathione acts as an antioxidant by quenching ROS and is involved in the ascorbateglutathione cycle that eliminates damaging peroxides

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It is now appreciated that substance P and its receptor are found in high quantities throughout the CNS

10.1016/j.tins.2011.09.001 43 HajimashhadiZ.AboutalebN.NasirinezhadF

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