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High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds

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Glycine betaine is the result of a two-step oxidation of choline by betaine aldehyde which is a toxic intermediate ( + dependent betaine dehydrogenase (BADH) ( in vivo varies among plant species and is between 40 and 400 mol g-1 (DW) in natural accumulation under stress conditions (Wani et al., 2013)

Dosing is always individualized based on the patients intake history and lab values rather than applied uniformly

doi: 10.1016/j.neuron.2012.09.020 225 MurataevaNMackieKStraikerA

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