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Hypothetically, for a patient with AS who has active sacroiliitis and subclinical colitis on biopsy, a biologically rational, though untested, regimen could pair a systemic biologic (such as a TNF or IL-17A inhibitor to suppress inflammation) with a gut-focused therapy (such as a probiotic or even FMT to restore microbiota and mucosal integrity)
Hart MP, Gitler AD
10.1038/s41467-022-32325-w 20 BarchielliG.CapperucciA.TaniniD
