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The release of free fatty acids from the hydrolysis of ester bonds in phospholipids has the potential to disrupt the liposomal membrane

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There is evidence that it is not GSNO per se but a degradation product of GSNO (namely glutathione disulfide-S-oxide) that results in protein S-glutathiolation [123,124], which may limit the biological importance of this reaction as it is not clear if these compounds can be formed from GSNO in vivo