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doi:10.1002/jor.21107 Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D

overactivation of PARPs, such as during extensive genotoxic stress, can result in significant NAD + depletion and subsequent compromise of cellular energy homeostasis

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The most common cause for this condition is pinching (entrapment) of the nerve as it enters the thigh travelling in close relation to a thigh ligament called the inguinal ligament