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These differences are determined by genetic factors and nongenetic variables such as age, sex, liver size, liver function, circadian rhythm, body temperature, and nutritional and environmental factors such as concomitant exposure to inducers or inhibitors of drug metabolism

Some studies have indicated that non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the activation and aggregation of neutrophils, decreasing their role in the inflammatory response after myocardial infarction (171)

Resveratrol ameliorates cardiac remodeling in a murine model of heart failure with preserved ejection fraction

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