Reported benefits (per available research): Studied for restoring more youthful pulsatile GH and IGF-1 secretion in older adults, based on a small 1997 randomized, placebo-controlled human trial of a closely related GHRH(1-29) analog published in the Journal of Clinical Endocrinology & Metabolism May support gains in lean body mass in men specifically: that same 16-week trial found a statistically significant increase in lean body mass in men but not in women, alongside a significant increase in skin thickness (a marker of dermal collagen) in both sexes Proposed to support broader recovery and body-composition goals tied to growth-hormone-axis activity, though sermorelin-specific modern adult trial data remains thin, and much of the anti-aging and muscle-building framing used in commercial marketing outpaces the current clinical evidence base Known risks and side effects: Injection-site reactions (pain, swelling, or redness) are the most commonly reported adverse event associated with sermorelin therapy in manufacturer drug-labeling data Headache, flushing, dizziness, difficulty swallowing, hyperactivity, drowsiness, and hives have also been reported less commonly per that same labeling data
The Prime Script RT Reagent Kit (Takara, Japan) was used to synthesize complementary DNA (cDNA), and qRT-PCR was performed using the SYBR Green Premix Ex Taq (Takara, Japan) on the LightCycler480 instrument (Roche) according to standard protocols
Seronegative patients also had fewer SARS-CoV-2-specific CD4 T cells than seropositive patients or controls
Data availability The data supporting the results of this study are available upon request from the corresponding author
doi: 10.1097/NEN.0b013e31827bfc62 133 CencioniMTMattoscioMMagliozziRBar-OrAMuraroPA
To this end, we performed a post hoc analysis on a subset of the study population that is characterized by increased oxidative stress, as determined by the values above the median for MDA, while showing low levels of baseline glutathione levels, as characterized by values below the median
