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Briefly, the colon was harvested, washed with ice-cold 1X PBS, opened longitudinally to remove luminal content and finally cut into small pieces of 12 mm

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146 These findings position ERAD as a critical safeguard of endocrine pancreatic function and a potential therapeutic target for diabetes

After binding to the GHR, the intracellular Janus kinase-2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and ERK1/2 pathways are activated [8]

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