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In the SCALE Sleep Apnea RCT, liraglutide 3.0 mg was associated with a significant reduction of apnea-hypopnea index (AHI) compared to placebo (6.1 events per hour, 95% 11 to 1.2 events per hour) at 32 weeks in patients with moderate to severe OSA not on positive airway pressure 20

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Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial

Limitations: Modern ophthalmology has not adopted this research