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Mechanistically ( Table 1 ), 1,25(OH) 2 D 3 downregulates master transcription factors driving Th1 ( + cytotoxic T lymphocytes (CTL) are similarly subject to 1,25(OH) 2 D 3 regulation: 1,25(OH) 2 D 3 reduces perforin and granzyme B expression, decreases pro-inflammatory cytokine production, thereby attenuating cytotoxic potential ( Figure 1D )

Glutathione, the main acting substrate of cellular resistance to oxidative stress, involves several enzymes in its metabolism (Tsugawa et al

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The agencys decision to adjust category listings is a procedural move rather than a safety validation