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Published in vitro and animal-model research has examined NNMT inhibition in connection with several areas of scientific interest, including adipocyte metabolism, NAD pathway regulation, mitochondrial function, and cellular energy signaling

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Against retinoids: GHK-Cu in the Abdulghani trial outperformed tretinoin without the irritation, peeling, and sun sensitivity that retinoids commonly cause

Works through a different pathway (NNMT vs

Badenhorst 2016 measured wrinkle volume reductions up to 55.8% and depth reductions of 32.8% over 12 weeks of topical use