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Laboratory investigations commonly examine 5-Amino-1MQs interaction with nicotinamide N-methyltransferase (NNMT) , an enzyme involved in cellular methylation balance and metabolic signaling networks

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Renal impairment reduces B12 excretion, leading to accumulation

Parsons RB, Smith EL, Waring RH, Ramsden DB

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prospective studies of larger patient populations may contribute to establish criteria for optimal antibody selection and timing of treatment, as well as to define their overall efficacy, which in turn should meaningfully inform real world practice [84]