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SKU: 9841076146
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10.1136/bmjmed-2022-000152 136

2017;13(3):317.e1

Even when severe, isolated selenium deficiency does not usually result in obvious clinical illness

If this happens you may need to re-start the medication at a low dose for a while before starting to taper again

However, mSOD1 induces morphological and functional activation of microglia and when motor neurons are co-cultured with microglia, extracellular mSOD1 injures motor neurons