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[DOI] [PubMed] [Google Scholar] 18.Tamaddonfard E, Farshid AA, Samadi F, Eghdami K

Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

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Full normalization is more likely when underlying contributors like excess body fat, poor sleep, inflammatory diets, and chronic stress are addressed alongside treatment

When to seek medical advice: Persistent or worsening injection site reactions (increasing redness, warmth, or discharge suggesting infection) Severe or persistent headaches Chest pain or palpitations Unexplained muscle weakness or cramps New or worsening neurological symptoms despite treatment Unexpected bleeding or bruising For non-emergency concerns, contact your GP or NHS 111