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He et al., 2017

In sum, MSC-based ovarian regeneration sits at an inflection point: pre-clinical depth and early human feasibility have built a strong biological foundation, yet translation demands equally rigorous attention to manufacturing, safety and trial architecture

NO is produced in the brain by neuronal NO synthase (nNOS) and serves as a key second messenger for instance, regulating neuronal plasticity and survival (Nakamura and Lipton, 2016