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Deleting either CX3CR1 or its ligand CX3CL1 also impairs synapse elimination following sensory deprivation, such as whisker cauterization in rodents (188), further underscoring the importance of this pathway in activity dependent neural remodeling (186, 189)

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To sum up, aerobic exercise, particularly moderate-intensity activities like running and swimming, facilitates the activity of antioxidant enzymes (SOD, CAT, and GPx), helping to alleviate oxidative pressure and remain cellular redox balance

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