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10.1007/s10620-012-2112-9 93

BAs can interact with multiple receptors (FXR, TGR5, VDR, S1PR2, etc.), and these receptors can exhibit ligand-dependent biased agonism and engage in intricate crosstalk

This narrow focus on lipid metabolism overlooks other critical aspects of SS treatment, such as immunomodulatory therapies (e.g., biologics targeting B cells and T cells) and anti-inflammatory drugs commonly used to manage SS-related symptoms

Pharmaceutics (2023) 15(2):664

Targeting these pathways, therapies such as the TLR4 antagonist ApTOLL, the iron chelator deferoxamine, and the free radical scavenger Edaravone have shown promise

Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways