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Beti C, Stratmann B, Bokman G, et al

They revealed that U-STAT3 interacted with the NF-B complex in cytoplasm, competing with the binding of IB proteins which are specific inhibitors of NF-B activation

This may also account for increased incidence of chronic kidney disease and end-stage renal failure in populations with chronic low Cd exposure (CLCE) (Satarug 2018