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CRP levels lack diurnal rhythm and its liver production is stimulated by cytokines including IL-6 and IL-17, which are upregulated by sleep deprivation 203

Sarzani R, Landolfo M, Di Pentima C, Ortensi B, Falcioni P, Sabbatini L, Massacesi A, Rampino I, Spannella F, Giulietti F (2024) Adipocentric origin of the common cardiometabolic complications of obesity in the young up to the very old: pathophysiology and new therapeutic opportunities

Most of the NAD in the body is synthesized from these precursor molecules using various cellular pathways

And while its unlikely that any serious side effects would occur given what we know about its ingredients, the fact that its an unaddressed possibility is concerning

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Stearoyl-CoA desaturase 1 inhibition impairs triacylglycerol accumulation and lipid droplet formation in colorectal cancer cells