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doi:10.3816/CCC.2009.n.034

149 StockwellB

J Biol Chem 277:1789217900

PMID: 37597256 Br J Pharmacol2023 Feb;180(3):287-307

NNMT is a cytosolic enzyme

In Men: Hair loss typically starts at the temples and crown Sons of bald fathers have 56 times higher relative risk Over 50% of white men show visible signs by age 50 The earlier it starts, the more aggressive the progression tends to be In Women: Hair loss presents as diffuse thinning a widening part, smaller ponytail, overall reduction in density The frontal hairline is usually preserved (unlike male pattern) Affects women of all ages, especially post-menopause due to declining estrogen Both sexes can be affected