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10.1016/j.phrs.2020.104856 136 PastoriV.TavazziS.LecchiM

567,568 For example, tannic acid could bind to the GPX4 activation site, enhancing its activity and cellular level, which in turn regulated amyloid and tau protein deposition by reducing oxidative stress and inhibiting ferroptosis, 569 providing a promising therapeutic avenue for combating the interaction between ferroptosis and AD

Dichloroacetate, a PDK inhibitor, induces the metabolic switch from glycolysis to OXPHOS to generate ROS accumulation, thereby facilitating ferroptosis [119] [Figure 4B]