We invited guest bloggers to comment on the guidelines including two very popular blogs by Bruce Wolffenbuttel: and Alfie Thain: Only One Chance Pernicious Anaemia: A Misnomer
Being deficient in vitamin B12 has been linked to anxiety due to the way B12 deficiencies trigger symptoms in red blood cells and the nervous system, and interfere with brain chemistry
NovoCare (manufacturer-direct, no membership): Wegovy pill $149/mo starting dose, Wegovy pen $199/mo first two fills then $349/mo
Vitamin B12, also known as cobalamin, is an essential nutrient that your body needs but cannot produce on its own[1]
Individuals who maintain a healthy lifestyle and consume a well-balanced diet may experience longer-lasting benefits from B12 injections
Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1
