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FL_14_CCxC QVTLKESGPALVKPTQTLTLTCTFSGFSLSNARMGVSWIRQPPGKCLEWLAHI D3-scFc FSNDEKSYSTSLKSRLTISKDTSKSQVVLTMTDMDPEDTATYYCARIVGYGTG scFv WYGFFDYWGQGILVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGD RVTITCRTSQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTE FTLTISSLQPEDFATYYCLQHNSYPLTFGCGTKVEIKS 536

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This inhibition disrupts L-ornithine hydroxylation, a critical step in siderophore production, resulting in iron starvation and suppressed fungal growth (Martn Del Campo et al., 2016

An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability

By addressing these future directions, the field can move toward a more mechanistic and translational understanding of astrocyte-mediated vascular pathology in PD