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For instance, erastin, a selective System Xc inhibitor, induces ferroptosis and AKI in renal TECs ( /GSHGPX4 axis in I/R AKI

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showed that hypoxia markedly enhances the tenogenic differentiation of adipose-derived mesenchymal stem cells in co-culture with tenocytes by upregulating HIF-1, while HIF-1 inhibition suppresses this response, and FG-4592 mediated stabilization of HIF-1 further amplifies it, identifying HIF-1 as a key driver of adipose-derived mesenchymal stem cell commitment toward a tenocyte lineage (Yu Y

This approach requires a nuanced understanding of the differential regulation of ferroptosis in tumor versus normal cells, and the development of precise therapeutic regimens that maximize efficacy while minimizing collateral damage

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