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Rarely, this can be life-threatening

SATB2 defect promotes colitis and colitis-associated colorectal cancer by impairing Cl-/HCO3- exchange and homeostasis of gut microbiota

doi: 10.1074/jbc.RA118.002838

Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion

RhGLP-1 (7-36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD