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Checkpoint kinase 2 (Chk2), a cell cycle checkpoint protein, is situated at the spindle poles and contributes to spindle assembly (23) During the MI and MII stages of mouse oocyte meiosis and early embryonic development, when chromosomes are properly aligned to form a spindle, Chk2 is localized at the spindle poles to facilitate spindle-related processes

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On the other hand, some beta-blockers and ACE inhibitors dont directly affect B12 levels