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have demonstrated that HIF-1 promotes bone resorption mediated by osteoclasts (OCs), while angiopoietin-like 4 (ANGPTL4) compensates for HIF-1s inadequate stimulation of OC activity and promotes the proliferation and differentiation of osteoblasts (OBs) (138)

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To protect mitochondrial oxidative damage, several mitochondrial-targeted antioxidants have been developed and a great potential mitochondrial-targeted antioxidant is MitoQ

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Characterization of phosphatidylserine synthase from Saccharomyces cerevisiae and a mutant defective in the enzyme