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doi:10.1371/journal.pone.0101956

These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

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Mitochondrial dysfunction in aging

Previous FDA panels have largely been composed of academics and researchers

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B 12 status compared with pregnant women of European ethnicity