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In line with our results from our mouse models, these data from clinical tumor samples further support the importance of fine-tuning the redox state in concert with inactivation of A2AR signaling in intratumoral CD8 + T cells for favoring the antitumor immune response

Since gene therapy is still being investigated in two phase I/II clinical trials (39), liver transplantation is established and would at present serve the same purpose

Int J Mol Med 57(5):109 Tang SP, Mao XL, Chen YH, Yan LL, Ye LP, Li SW (2022) Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death

Population pharmacokinetic analysis from phase I and phase II studies of the humanized monovalent antibody, onartuzumab (MetMAb), in patients with advanced solid tumors

[DOI] [PubMed] [Google Scholar] 192.Soterakis J, Iber FL

5 Prospects Ferroptosis is a regulated form of cell death characterized by iron-catalyzed lipid peroxidation and can be modulated through various mechanisms