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Concentration-Efficacy Relationships The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with opioid agonists

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It is often indicated when oral medications fail to provide adequate symptom control and is preferred over more invasive interventions like deep brain stimulation (DBS) or LD/CD intestinal gel [148]

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Interestingly, this effect appears to be context-dependent, that is, robust in vivo, but not consistently observed in isolated in vitro models