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Vinjamoori and Egler do have a point

S2CID 24730915

When an HBGV is available, risk characterization is performed based on metrics such as the Hazard Quotient (HQ) or the Margin of Safety (IPCS 2009

Furthermore, human glioblastoma cells do not rely much on circulating glutamine for proliferation but rather more on glutamate to synthesize glutamine via glutamine synthetase to fuel purine biosynthesis 193