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In addition, the increase in carbonylated proteins and lipid hydroperoxides in mitochondria, as well as the abnormally high rates of production of hydrogen peroxide in SOD1 G93A transgenic mice (Mattiazzi et al., 2002

Similar to normal cells, tumor cells generate ammonium primarily via amino acid deamination, notably through the glutamine cycle, where glutamate dehydrogenase (GDH) catalyzes glutamate deamination to produce free ammonium and -KG

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This entire process is known as molecular mimicry

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Notably, after oxidation both products will bind to DNA, which increases their fluorescence