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GAGs are a group of polysaccharide molecules, also known as mucopolysaccharides, that create the foundational structure of the extracellular matrix (ECM), together with other components such as collagen, elastin, fibronectin, and laminin Biomechanically, the layer of GAGs functions as a hydrated gel that provides cushioning and resists compressive forces

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For example, functional TGFB1 promoter polymorphisms correlate with greater circulating TGF-1, adverse clinical features, and dismal survival trajectory in patients with brain malignancies (59)