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Subsequent research in PD mouse models demonstrated a toxic synergy between mutant -syn (-syn-A53T) and iron deposition, inducing cellular senescence in the SN prior to DA neuron loss and the onset of motor deficits (Shen Q

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However, it is important to note that ferroptosis is a double-edged sword

The data confirms that the 5-membered rings are more kinetically stable and thus formed at a faster rate under conditions of rapid oxidation