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Subcutaneous administration of zoledronic acid to rabbits during organogenesis did not cause adverse fetal effects at up to 0.4 times the human 5 mg intravenous dose (based on body surface area, mg/m2), but resulted in maternal mortality and abortion associated with hypocalcemia starting at doses equivalent to 0.04 times the human 5 mg intravenous dose

Hrelec M, Klicek R, Brcic L, et al

doi: 10.1172/JCI148546 35 ChenSSaeedAFUHLiuQJiangQXuHXiaoGGet al

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Brennan PA, Umar T, Smith GI, Lo CH, Tant S