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Monsen AL, Refsum H, Markestad T, Ueland PM

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Folate- and vitamin B12-deficient diet during gestation and lactation alters cerebellar synapsin expression via impaired influence of estrogen nuclear receptor

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The mechanism is related to metabolic regulation and increased chemosensitivity of cancer cells: by inhibiting NNMT, the product disrupts the energy supply of cancer cells, making them more vulnerable to chemotherapy, while protecting the metabolic balance of normal cells and reducing side effects