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Consequently, mTOR impairment resulted in an increase in autophagy

The protein-protein interaction (PPI) network was built starting from a small group of proteins selected from the literature showing a significative evidence to be functionally correlated with the circadian molecular clock

doi: 10.3748/wjg.v17.i43.4779 112 KoustasESarantisPTheoharisSSaettaAAChatziandreouIKyriakopoulouGet al

In sepsis, LPS binds to the TLR4-MD2-CD14 receptor on lung cells, activates the MyD88-dependent signaling pathway, promotes the ubiquitination of TRAF6 and activates the TAK1/IKK/NF-B pathway, inducing the release of pro-inflammatory factors such as TNF- and IL-1 (162, 163)

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Indian J Surg 84(5):913921 Schmassmann A, Zoidl G, Peskar BM, Waser B, Schmassmann-Suhijar D, Gebbers J-O et al (2006) Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and-2 knockout mice