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In ferroptosis, accumulation of intracellular iron ions triggers an elevated production of free radicals, potentially surpassing the cellular reductive capacity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Sun J, Shen X, Li Y, Guo Z, Zhu W, Zuo L, Zhao J, Gu L, Gong J, Li J

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Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair

This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)