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Curr Biol , 2020, 30: R1292R1297 Jiang X, Stockwell BR, Conrad M

Mechanistically, TXNIP functions as a Trx1 antagonist, suppressing its redox-regulatory capacity through direct binding (46)

Mitochondrial dysfunction plays a central role, leading to impaired oxidative phosphorylation, reduced adenosine triphosphate (ATP) generation, and increased oxidative stress, all contributing to cellular damage and death [2]