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It consists of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) and is widely studied in preclinical models for tissue repair, angiogenesis, gastroprotection, and tendon/ligament healing

BER enzymes are primarily targeted at removing N7-MeG and N3-MeA lesions, subsequently repairing the DNA through the collaborative action of DNA polymerase and DNA ligase, thus restoring the DNA strand to its original, non-damaged state [165]

Expression was then induced by addition of 0.2 mM IPTG and the cells were further grown overnight

*Correspondence: Mohd Esa Norhaizan [email protected] Present Address: Heshu Sulaiman Rahman, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia

doi: 10.1074/jbc.275.18.13259

Viral or bacterial cross-infections, especially in early life, which may occur more frequently in larger families, have been discussed to have a protective role against atopic disease by preventing proliferation of Th2-lymphocytes (Romagnani, 1992b